GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs4808801 | 1 | rs10409483 | chr19:18590223 | LRRC25 | chr19:18501955-18508421:- | -0.14 | -6.82 | 1.55E-11 | Breast cancer |
| BRCA | cis | rs4803468 | 1 | rs10409485 | chr19:41920765 | B3GNT8 | chr19:41931265-41934635:- | 0.25 | 7.69 | 3.33E-14 | Height |
| BRCA | cis | rs4808801 | 1 | rs10409505 | chr19:18590251 | LRRC25 | chr19:18501955-18508421:- | -0.14 | -6.82 | 1.55E-11 | Breast cancer |
| BRCA | cis | rs4808801 | 1 | rs10411009 | chr19:18606266 | LRRC25 | chr19:18501955-18508421:- | -0.13 | -6.62 | 5.57E-11 | Breast cancer |
| BRCA | cis | rs8101881 | 1 | rs10412219 | chr19:33413246 | SLC7A9 | chr19:33321421-33360683:- | -0.19 | -5.46 | 5.93E-8 | Blood metabolite levels;Urinary metabolites (H-NMR features);Urinary metabolites |
| BRCA | cis | rs10412972 | 1 | rs10412972 | chr19:52154905 | KLK14 | chr19:51581154-51587502:- | -0.17 | -3.49 | 0.000501 | Plasma plasminogen levels |
| BRCA | cis | rs10412972 | 1 | rs10412972 | chr19:52154905 | SIGLEC14 | chr19:52145808-52150132:- | -0.18 | -4.36 | 1.45E-5 | Plasma plasminogen levels |
| BRCA | cis | rs10412972 | 1 | rs10412972 | chr19:52154905 | ZNF577 | chr19:52359056-52394145:- | -0.16 | -3.44 | 0.000614 | Plasma plasminogen levels |
| BRCA | cis | rs3745672 | 1 | rs10413462 | chr19:12054636 | ZNF763 | chr19:12035900-12091196:+ | -0.35 | -5.92 | 4.27E-9 | Multiple sclerosis |
| BRCA | cis | rs4803468 | 1 | rs10413735 | chr19:41921071 | B3GNT8 | chr19:41931265-41934635:- | -0.24 | -7.34 | 4.36E-13 | Height |
| BRCA | cis | rs11083475 | 1 | rs10415219 | chr19:39150235 | LGALS7 | chr19:39261608-39264157:- | -0.17 | -5.28 | 1.53E-7 | Heart rate |
| BRCA | cis | rs8170 | 1 | rs10416654 | chr19:17385176 | ANKLE1 | chr19:17392454-17398454:+ | 0.21 | 5.95 | 3.59E-9 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs8170 | 1 | rs10416654 | chr19:17385176 | ANO8 | chr19:17434032-17445638:- | 0.14 | 3.47 | 0.000547 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs8170 | 1 | rs10416654 | chr19:17385176 | OCEL1 | chr19:17337055-17340027:+ | 0.15 | 4.63 | 4.02E-6 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs4803468 | 1 | rs10417311 | chr19:41902038 | B3GNT8 | chr19:41931265-41934635:- | -0.24 | -7.37 | 3.52E-13 | Height |